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  • Glioblastoma therapy enabled by magnetic nanocomplexes; Apoptosis signaling pathway analysis

  • Habib Ghaznavi,1 Milad Shirvaliloo,2 Roghayeh Sheervalilou,3,*
    1. Zahedan University of Medical Sciences
    2. Tabriz University of Medical Sciences
    3. Zahedan University of Medical Sciences


  • Introduction: This study introduces an effective magnetohyperthermia (MH)-based therapy for deep-seated tumors, particularly glioma.
  • Methods: The therapy leverages magnetic graphene oxide (GOMNPs) nanoheaters to combine magnetothermal effects with reactive oxygen species (ROS) induction, addressing limitations in current magnetothermal strategies.
  • Results: These 34 nm GOMNPs, with a -35 mV surface charge, exhibited low toxicity. Under an alternating magnetic coil (AMC), GOMNPs showed a high specific absorption rate (SAR, P<0.01) and increased ROS production within the tumor. Significant therapeutic efficacy was observed with 30 mg/kg GOMNPs after three alternating magnetic field (AMF) treatment courses, outperforming AMF alone (P<0.05). GOMNPs demonstrated potent anti-glioma effects by inhibiting tumor growth and improving survival rates through induced apoptotic cell death (P<0.05). This was further supported by a higher Bax/Bcl2 protein and gene ratio in the MH-treated group.
  • Conclusion: The combination of magnetohyperthermia with conventional modalities holds immense potential for clinical advancements over existing methods.
  • Keywords: Glioblastoma therapy, magnetic nanocomplexes, Apoptosis signaling pathway

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