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  • Investigation of Hexokinase Enzyme in Brain Cancer

  • dariush norozian,1,* mahla bakhshi,2


  • Introduction: Brain cancer is one of the neoplastic tumors with complex clinical features that, due to the rapid and invasive growth of cancer cells, poses major therapeutic challenges. Since cancer cells require large amounts of energy for survival and proliferation, metabolic pathways that provide this energy have been recognized as potential therapeutic targets. Carbohydrates are the primary source of nutrition for cancer cells, and their excessive consumption may play a critical role in the initiation and progression of brain tumors. Among the key metabolic pathways, glycolysis plays a central role in cellular energy production, while alterations in the activity of enzymes involved in this process can directly affect tumor development. Hexokinase, particularly its isoforms HK1 and HK2, is of special importance in this regard.
  • Methods: Methods: Bioinformatics analyses were performed using the MEGA-GEN software to evaluate genes, proteins, polymorphisms, and SNPs associated with hexokinase in brain tumors.
  • Results: Results: The findings indicated that the AKT1 gene enhances hexokinase 2 activity and glucose uptake, while the HIF1A protein increases HK2 expression under hypoxic conditions. In addition, metabolic networks and gene regulatory pathways associated with hexokinase were identified and analyzed.
  • Conclusion: Conclusion: A comprehensive analysis of these mutations and metabolic pathways highlights the pivotal role of hexokinase 2 as a potential therapeutic target. These findings provide a foundation for future experimental and clinical studies aiming to develop targeted therapies for brain cancer.
  • Keywords: Hexokinase, Brain Cancer, Glycolysis, Bioinformatics, SNPs

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