INTERNATIONAL CONGRESS OF
CancerGenetics
Garlic consumption has a potentially favorable effect against colorectal cancer (CRC)
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Zahra Amirkhani,1,* Aidin Amini Sefidab,2 Ali Movassagh,3 Ali Rezaeian,4
1. Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran
2. Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran
3. Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran
4. Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran
- Introduction: Colorectal cancer (CRC) is the most common cancer of the gastrointestinal tract and is one of the most frequently diagnosed malignancies in adults. Colorectal cancer is common, accounting for 15% of all newly diagnosed cancers, and tends to be a disease of the elderly, with the median age of diagnosis between 60 and 80 years of age, slightly younger for rectal cancer. There is also a slight male predilection for rectal cancers, not found in tumors elsewhere in the colon. Garlic (Allium sativum) has been used medicinally for over 5000 years, but in the last 30 years, a considerable body of evidence has sought to link extracts of the vegetable or its active ingredients to physiological processes and to a role in the prevention or management of human disease. Claims have been and are being made for a role of garlic in antibacterial, antiviral, antiinflammatory, and antineoplastic activities. Moreover, some evidence exists that it may prevent colorectal tumor formation, reduce cholesterol, reduce blood pressure (BP), provide anticoagulation, and provide broad antioxidant activity to limit free radical damage. Garlic has been used globally in numerous ways. Some evidence has suggested that garlic consumption can lower CRC risk. The purpose of this review study is to focus on the Garlic is used to prevent colorectal cancer
- Methods: We conducted a comprehensive search for relevant studies in PubMed, Scopus, and SID databases, as well as the Google Scholar search engine. The advanced search keywords included " Colorectal cancer " " Garlic " " Diet " . The search was restricted to studies published in English with accessible full texts. Review articles, duplicates, and non-relevant studies were excluded
- Results: Based on the existing evidence, garlic intake could reduce the risk of CRC. The cancer-prevention mechanism of garlic remains unclear. S-allylmercaptocysteine, the water-soluble derivative of garlic, has been found to display anti-proliferative capacity in numerous cancer cell lines, and it has also shown tumor-inhibiting effects in in vivo conditions. Garlic can enhance the anticancer ability by activating the antioxidant transcription expression of Nrf2 and the downstream gene NQ01. Aged black garlic (ABG) can modify the mRNA expression of neuropeptides and proteins in the case of inflammation. Alternatively, ABG can exert its anticancer function by suppressing the proliferation of cells. Garlic is potentially potent against some types of cancers; importantly, it is a universal anticancer drug that is potent against different cancers; this effect is achieved by suppressing the growth of cancer cells and effectively suppressing the proliferation of infiltrative macrophages within the tumor-like microenvironment. A large amount of preclinical data suggests that garlic has a certain effect on modulating the metabolism of carcinogens, inhibiting the progression of the cell cycle, inducing apoptosis and histone modification, and inhibiting angiogenesis.
- Conclusion: We conducted a comprehensive search for relevant studies in PubMed, Scopus, and SID databases, as well as the Google Scholar search engine. The advanced search keywords included " Colorectal cancer " " Garlic " " Diet " . The search was restricted to studies published in English with accessible full texts. Review articles, duplicates, and non-relevant studies were excluded
- Keywords: Colorectal cancer, Garlic, Diet
