INTERNATIONAL CONGRESS OF
CancerGenetics
Protein Nanoparticles in tumor targeting
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Fereshteh Alizadeh,1,*
1. phd student of nanobiotechnology, tarbiat modares university, tehran, iran
- Introduction: Proteins are linear polymers that are composed of amino acids and have different structures and functions. They can be classified according to their solubility, chemical structure, shape and number of monomers. In view of the physicochemical properties and degradability of proteins, they play an important role in the development of nanoparticles as carriers of drugs and biological compounds. The development of drug delivery systems using nanoparticles as carriers for small and large therapeutic molecules is a growing area of research. The advantages of using proteins to produce nanoparticles for drug delivery and imaging applications are: their abundance of natural sources, their biocompatibility, their biodegradability and the ease of the synthesis process. Unlike metal nanoparticles, protein nanoparticles have no limitations such as potential toxicity, large size, accumulation or rapid excretion from the body. In addition, the surface of protein nanoparticles can be modified with protein ligands, carbohydrates, etc. protein nanoparticles can Protein nanoparticles can target tumor cells with three methods of active targeting, passive targeting and physical targeting
- Methods: This review article has been collected from reliable scientific sources and is the result of studying many researches of the authors.
- Results: The use of protein nanoparticles for such applications may be a better alternative to improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules.
- Conclusion: The development of nanoparticle drug delivery systems is expected to have a major impact on the treatment of cancers and other life-threatening diseases. There is a great need to identify nanoparticle materials that are safe and effective in delivering therapeutic agents to the target sites. Protein polymers from natural sources are promising materials for constructing the nanocarrier systems.
- Keywords: Drug delivery, Nanotechnology, Protein Nanoparticles
