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INTERNATIONAL CONGRESS OF

CancerGenetics

• Tissue Engineering Scaffolds Loaded With a Variety of Plant Extracts: Novel Model in Breast Cancer Therapy

• reyhaneh azhari rad,^1,* yasaman naghdi,²
  1. Student Research Committee, School of Paramedicine, Shahroud University of Medical Sciences, Shahroud, Iran
  2. Student Research Committee, School of Paramedicine, Shahroud University of Medical Sciences, Shahroud, Iran
  
  
  
• Introduction: Despite notable advances in breast cancer (BC) diagnosis and treatment, it remains a global health concern due to the high prevalence, adverse side effects of conventional therapies, and recurrence risks. Chemotherapy, while effective, often leads to severe complications such as congestive heart failure. Growing concern over these limitations has prompted researchers to explore safer and more targeted therapeutic strategies. This review focuses on the integration of plant extract–loaded scaffolds into tissue engineering as a novel approach to BC treatment, emphasizing their role in enhancing drug delivery and reducing recurrence.
• Methods: A comprehensive literature search was conducted across databases including PubMed, Scopus, and Web of Science. Keywords such as "breast cancer," "plant extracts," "tissue engineering," "scaffolds," and "targeted drug delivery" were used. Peer-reviewed articles from the last decade were analyzed to assess the role of natural compounds and bioengineered scaffolds in BC therapy
• Results: Recent studies highlight the potential of combining plant-derived compounds such as α-mangostin and lentinan with nano-fibrous (NF) scaffolds to overcome limitations in traditional therapies, including poor drug solubility, low bioavailability, and systemic toxicity. These plant extract–infused scaffolds enhance localized drug delivery, suppress tumor cell viability, and reduce the risk of recurrence post-surgery. Notably, α-mangostin exhibits strong antibacterial activity against Gram-positive bacteria, contributing to post-operative infection control. Additionally, composite NFs loaded with polymers like PLGA/PEG have demonstrated improved mechanical strength, biocompatibility, and controlled drug release, which are crucial for long-term therapeutic efficacy. Targeted scaffolds can also down-regulate oncogenic markers such as HER3, further supporting their role in comprehensive BC management.
• Conclusion: Plant extract–loaded scaffolds represent a promising frontier in BC therapy by enabling personalized, targeted, and safer treatments. Their ability to deliver anticancer agents precisely to tumor sites reduces systemic side effects and enhances therapeutic outcomes. The incorporation of nanotechnology and natural compounds into scaffold design not only addresses long-standing challenges in chemotherapy and surgical recovery but also paves the way for next-generation treatments that may significantly reduce local recurrence rates. Further in vivo and clinical investigations are essential to fully realize their therapeutic potential.
• Keywords: Tissue engineering, scaffolds, plant extracts, breast cancer, treatment