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INTERNATIONAL CONGRESS OF

CancerGenetics

• Cancer rate in children from ICSI method

• Sajad Sepehrirad,¹ Saba Safdarpour,^2,* Sarah Mohammaditirabadi,³
  1. Faculty of Modern Sciences, Islamic Azad University of Medical Sciences, Tehran, Iran
  2. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. Department of biology, College of Science, University of Tehran, Tehran, Iran
  
  
  
• Introduction: BACKGROUND: The first fertility child was born in the world's laboratory conditions in the 1900s. Since then, more than 8 million children have been created entire the world with reproductive technologies (ART) and a significant portion of them have reached puberty or adulthood. There is increasing evidence that ART methods can disrupt epigenetic processes during the preimplantation period and affect long-term health; And in general, these fertility induction methods can have positive effects and negative aspects in the long run. One of the negative effects can be the increased risk of cancer in children from the ICSI method. We will address this issue in this research. OBJECTIVE: The purpose of this study is whether or not there is a relationship between the occurrence of cancer in children and ICSI infertility treatment method; And if there is, what is the risk of cancer.
• Methods: METHODS: In our review article, we searched PubMed, ScienceDirect, Google Scholar, and Scopus for relevant articles published between 2018 and 2024, using keywords like Infertility; Cancer; Assisted reproductive technology (ART); and Intracytoplasmic sperm injection (ICSI).
• Results: RESULTS: Recent studies have shown that there is an increasing relationship between the occurrence of various types of cancer in children and ICSI fertility induction method. Alternatively, ICSI has been reported to increase the incidence of chromosomal abnormalities and blood pressure disorders. Also, another study showed that male ICSI offspring had lower HDL levels at 18 years of age than naturally conceived males. But it should be noted that the observed increased risk among children conceived using ICSI must be interpreted with caution owing to the small number of cases. Interestingly, research on mice has shown that assisted reproductive techniques like ICSI can induce morphological and functional defects that may only become evident after germline transmission to subsequent generations.
• Conclusion: CONCLUSION: This suggests potential long-term effects that may not be immediately apparent While direct evidence linking ICSI to cancer in offspring is lacking in the provided context, the studies emphasize the need for continued long-term follow-up of ICSI children. The observed increased risks of various health issues, including congenital malformations and chromosomal abnormalities, warrant ongoing monitoring and research to fully understand any potential cancer risks.
• Keywords: Cancer, ICSI, ART, Fertility induction method