INTERNATIONAL CONGRESS OF
CancerGenetics
Colorectal cancer and Bacteroides fragilis
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Hanieh Safarzadeh,1 Siamak Heidarzadeh,2,*
1. Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zan-jan, Iran; haniehsafarzadeh1@gmail.com
2. Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zan-jan, Iran; haniehsafarzadeh1@gmail.com
- Introduction: Colorectal cancer (CRC) is a common and deadly cancer worldwide. Recent research has identified the gut bacterium Bacteroides fragilis, particularly its enterotoxigenic strain (ETBF), as a significant player in the development of CRC.
- Methods: This study reviews existing literature on the relationship between Bacteroides fragilis and colorectal cancer. We searched databases like PubMed and Scopus using keywords such as "colorectal cancer" and "Bacteroides fragilis," and analyzed relevant studies.
- Results: The findings suggest a strong link between Bacteroides fragilis and CRC. ETBF produces toxins that cause inflammation and damage the gut lining, contributing to cancer development. The presence of ETBF could also be a potential biomarker for early CRC detection.
- Conclusion: The connection between Bacteroides fragilis and colorectal cancer highlights the importance of gut microbiota in cancer. Targeting this bacterium could be key in preventing and treating CRC.
- Keywords: Colorectal cancer, Bacteroides fragilis, gut microbiota
