INTERNATIONAL CONGRESS OF
CancerGenetics
Possible effect of Propionibacterium acnes in prostate cancer
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Hanieh Safarzadeh,1 Siamak Heidarzadeh,2,*
1. Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zan-jan, Iran; haniehsafarzadeh1@gmail.com
2. Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zan-jan, Iran; haniehsafarzadeh1@gmail.com
- Introduction: Propionibacterium acnes (P. acnes) is a Gram-positive anaerobic bacterium traditionally known for its role in acne vulgaris. However, emerging evidence suggests that P. acnes may also be implicated in the development and progression of prostate cancer (PCa)
- Methods: A PubMed search was conducted using the terms " Propionibacterium acnes " and " prostate cancer". Only English articles published within the last five years were included
- Results: The expression of IL-6 and TNF-α is significantly higher in P. acnes-containing prostate cancer tissues compared to bacteria-free tissues, suggesting a possible link between P. acnes-induced inflammation and prostate cancer progression
- Conclusion: The findings of this study support the hypothesis that P. acnes may play a contributory role in the pathogenesis of prostate cancer, possibly through mechanisms involving chronic inflammation. The significant association between P. acnes presence and elevated levels of pro-inflammatory cytokines in prostate cancer tissues suggests that P. acnes-induced inflammation could be a driving factor in prostate carcinogenesis
- Keywords: Propionibacterium acnes, prostate cancer
