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INTERNATIONAL CONGRESS OF

CancerGenetics

• Genetic and Epidemiological Factors in Breast Cancer Incidence Among Women with a Family History

• Nedasadat safarabadi farahani,^1,* Maedeh chegini,² Azarmidokht Aminazad,³ Maryam Roosta,⁴ Motahare Mohammadi,⁵
  1. Islamic Azad University Science and Research Branch
  2. Islamic Azad University, North Tehran Branch
  3. Department of Medical Sciences, Faculty of Medical Sciences, University of Tehran
  4. Department of Clinical biochemistry, Afzalipour School of Medicine , Kerman University of Medical Sciences
  5. Clinical Biochemistry,Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences
  
  
  
• Introduction: Breast cancer remains one of the most prevalent cancers among women worldwide. This study aims to investigate the genetic and epidemiological factors contributing to breast cancer in women with a family history of the disease. Specifically, we compare the frequency of breast cancer-related gene mutations (such as BRCA1 and BRCA2) in women with and without a family history of breast cancer. Additionally, we examine environmental and lifestyle factors that may influence breast cancer risk in women with a familial predisposition regarding questioner.
• Methods: This study involved a cohort of 500 women diagnosed with breast cancer, divided into two groups: those with a family history of breast cancer (250 women) and those without (250 women). The sample included 0 men and 500 women, with a mean age of 52.3 years. Genetic testing for BRCA1 and BRCA2 mutations was conducted, and data on environmental and lifestyle factors were collected through structured interviews and questionnaires.
• Results: Among the women with a family history of breast cancer, 125 (50%) tested positive for BRCA1 mutations, and 75 (30%) tested positive for BRCA2 mutations. In contrast, among the women without a family history, 25 (10%) tested positive for BRCA1 mutations, and 15 (6%) tested positive for BRCA2 mutations. Analysis of environmental and lifestyle factors indicated that women with a family history who engaged in regular physical activity had a 20% lower incidence of breast cancer, while those with high alcohol consumption had a 15% higher incidence.
• Conclusion: The findings suggest a significantly higher prevalence of BRCA1 and BRCA2 mutations in women with a family history of breast cancer compared to those without. Additionally, environmental and lifestyle factors play a crucial role in modulating breast cancer risk among genetically predisposed individuals. These results underscore the importance of genetic screening and lifestyle modifications in managing breast cancer risk in women with a family history of the disease.
• Keywords: Breast cancer, BRCA1, BRCA2, family history, genetic mutations, epidemiology, environmental factors,