INTERNATIONAL CONGRESS OF
CancerGenetics
A review of the role of telomerase in the response of breast cancer to treatment
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Maryam Mirzalou,1,*
1. Midwifery undergraduate student, Faculty of Medical Sciences, Marand Islamic Azad University, Department of Midwifery, Marand, Iran
- Introduction: Breast cancer is the most common cancer in the world, which is the cause of death caused by this particular type of cancer, affects women in developed and developing countries. Prevention and early detection are very important factors for prognosis that should be considered.
- Methods: To identify studies aimed at the role of telomerase in the response of breast cancer to treatment, this systematic review was searched in PubMed, Science Direct, and Google Scholar databases based on the keywords Telomerase, Breast cancer, and Treatment. After reviewing the summary of the articles and checking the title, the irrelevant articles were removed the full text of the articles was searched and the articles related to the topic were included in the study.
- Results: According to the studies, one of the prominent characteristics of cancer cell is the ability to divide indefinitely, which makes them immortal, and the telomeres that shorten with each cell division in normal cells are shortened by the telomerase enzyme in cancer cells. are regenerated, which is expressed in more than 85% of cancers. In this way, the low effectiveness of treatments has led to the search for new combined and more effective treatment methods, including the involvement of telomerase inhibitors and telomerase-tergeted immunotherapy.
- Conclusion: Telomerase may have different functions and high enzyme activity in cancer cells is related to poor cell sensitivity to treatments; Therefore, telomerase has become a potential target for cancer therapy.
- Keywords: telomerase, breast cancer, treatment
