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Accepted Articles of Congress

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  • Pseudogenes in colorectal cancer: A systematic review

  • Zahra Salehi,1,* Ali Asadzadeh,2 Parmida Bagheri,3 Alireza Zangooie,4 Helia Zangooie,5
    1. Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    2. Department of Biology, Payame Noor University, Shahre Rey, Iran
    3. Department of Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
    4. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjnad, Iran.
    5. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.


  • Introduction: Colorectal cancer (CRC) is a leading cause of oncologic death worldwide. Elucidating the molecular mechanisms that underpin its pathogenesis is essential for identifying novel therapeutic targets. Pseudogenes have historically been regarded as non-functional genomic vestiges but have gained recognition for their contributory roles in the oncogenesis of CRC.To systematically review and synthesize the existing evidence on the involvement of pseudogenes in CRC, we aim to assess their viability as diagnostic and prognostic biomarkers and evaluate their potential as innovative therapeutic targets
  • Methods: We conducted a comprehensive literature search following the PRISMA guidelines across PubMed, SCOPUS, and Web of Science databases. Two reviewers independently carried out the screening of studies and extraction of relevant data. Nineteen studies met the inclusion criteria. These studies highlight pseudogenes' emerging role in colorectal cancer, transitioning from being seen as evolutionary remnants to recognized contributors in tumorigenesis.
  • Results: The diagnostic and prognostic potential is found in pseudogenes like MYLKP1 (with SNPs rs12490683 and rs12497343) and POU5F1P1 (SNP rs6983267). Additionally, CDCP1, SUCLG2P2, and MT1DP offer prognostic insights, guiding personalized treatment approaches.
  • Conclusion: Our review illuminates the promise of pseudogenes as biomarkers and therapeutic targets, indicating a significant step towards the integration of pseudogenes in the future paradigm of precision medicine for CRC.
  • Keywords: Colorectal cancer, Pseudogene, Tumorigenesis, Gene regulation

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