INTERNATIONAL CONGRESS OF
CancerGenetics
A review of the pathology and prognostic factors of colorectal cancer
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Mahdiyeh Mirzalou,1,* Marziyeh Mirzalou,2
1. Bachelor student of microbiology, Islamic Azad Faculty of Biosciences and Technologies, Marand, Marand, Iran
2. Bachelor student of microbiology, Islamic Azad Faculty of Biosciences and Technologies, Marand, Marand, Iran
- Introduction: Colorectal cancer is a common and deadly cancer worldwide, and the risk of developing this cancer is influenced by environmental and genetic factors. This cancer can be diagnosed after the onset of symptoms or through screening of asymptomatic people.
- Methods: This systematic review was conducted to identify studies aimed at the pathology and prognostic factors of colorectal cancer, searching Google Scholar, Science Direct, PubMed databases based on the keywords Colorectal cancer, Pathology, Prognostic. After reviewing the summary of the articles and checking the title, the irrelevant articles were removed and the full text of the articles was searched and the articles related to the topic were included in the study.
- Results: According to the studies, the most powerful tool to evaluate the prognosis after potentially curative surgery for colorectal cancer is the pathological analysis of the resected specimen. Right and left colon cancers are microscopically similar and appear to have a similar prognosis when presenting with regional disease. However, in the setting of metastatic disease, at least some data suggest a worse prognosis for those with a right-sided primary tumor.
- Conclusion: Prognostic determinants are the most important outcome indicators after resection of colorectal cancer in the pathological stage at presentation. However, more recent data suggest that tumor size may be an adverse prognostic factor for colorectal cancer.
- Keywords: Colorectal cancer, Pathology, Prognosis
