INTERNATIONAL CONGRESS OF
CancerGenetics
The Role of Long Non-coding RNAs In Breast Cancer Progression and Potential Therapeutic Applications
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Anahita Bizhanpour,1,*
1. Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
- Introduction: Breast cancer continues to pose significant health challenges as the most common cancer in the world[1]. Among the many molecular entities implicated in its progression, long non-coding RNAs (lncRNAs) have emerged as important regulators of gene expression and cellular functions[2]. This essay reviews the roles of lncRNAs in breast cancer progression and treatment.
- Methods: lncRNAs play a crucial role breast cancer progression by regulating key significant pathways involves in cell proliferation, migration, invasion and metastasis. As an instance, long non-coding RNA known as LOC127814295 (lnc-RGS5) is notably overexpressed in breast cancer. Higher levels of lnc-RGS5 are linked to poorer overall survival in patients with triple negative breast cancer. In addition, upregulation of lnc-RGS5 promotes breast cancer cell proliferation in vitro, while its knockdown inhibits tumor cell proliferation both in vitro and in vivo[3].
- Results: Another example includes lncRNA NR2F1-AS1. High levels of lnc NR2F1-AS1 were found in BC cells undergoing EMT and were linked to poor prognosis in BC patients. Knocking down lnc NR2F1-AS1 significantly reduced BC cell migration, invasiveness, and metastasis[4]. Mechanistically, lnc NR2F1-AS1 binds to binds to miR-25-3p, preventing the degradation of ZEB2, a positive EMT transcription factor[5].
- Conclusion: In conclusion, whereas long non-coding RNAs (lncRNAs) are essential for the development of breast cancer, their functions go beyond just contributing to the pathophysiology of the illness. These compounds show potential as biomarkers and therapeutic targets, opening up new therapeutic options for the detection and management of breast cancer. By utilizing the special qualities of lncRNAs, we can improve patient outcomes by advancing our tactics against this common cancer.
- Keywords: Breast cancer, Long non-coding RNAs, lncRNAs
