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INTERNATIONAL CONGRESS OF

CancerGenetics

• A review of the role of microbial products in the development of colorectal cancer

• Marziyeh Mirzalou,^1,* Mahdiyeh Mirzalou,²
  1. Bachelor student of microbiology, Islamic Azad Faculty of Biosciences and Technologies, Marand, Marand, Iran
  2. Bachelor student of microbiology, Islamic Azad Faculty of Biosciences and Technologies, Marand, Marand, Iran
  
  
  
• Introduction: Colorectal cancer (CRC) is the third most common malignant cancer and the second leading cause of cancer-related death in the world. There are many microbes in the intestine that have the ability to process and use ingested food, and their products play a significant role in causing this cancer.
• Methods: In this systematic review, to identify studies aimed at the effect of the role of microbial products in the development of colorectal cancer, a search was conducted in Science Direct, Google Scholar, PubMed databases based on the keywords Colorectal cancer, Microbial products, Prevention. After reviewing the summary of the articles and checking the title, the irrelevant articles were removed and the full text of the articles was searched and the articles related to the topic were included in the study.
• Results: Human gut microbiome is a complex community consisting of bacteria, archaea, viruses and eukaryotes. Also, the intestinal microbiome can affect the chemotherapy of colorectal cancer, and the simultaneous use of Bifidobacterium long and Bifidobacterium short can improve cancer control and significantly reduce tumor progression.
• Conclusion: Colorectal cancer is a multifactorial disease and microbial dysbiosis in the human intestine has been identified as a risk factor. However, the molecular mechanisms that underlie the effects of intestinal microbial products have not yet been fully elucidated, and the effect of some products on this cancer is still controversial, but in short, intestinal microbial products play an important role in prevention. They have cancer from this.
• Keywords: Colorectal cancer, Microbial products, Prevention