INTERNATIONAL CONGRESS OF
CancerGenetics
Metabolic syndrome and cancer, looking at common pathways and mechanisms
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kimia parvardeh,1,*
1. tehran university of medical science
- Introduction: Increased consumption of high-calorie diets and insufficient physical activity are the main culprits of the growth of obesity and metabolic syndrome in the last century; the prevalence of various types of cancer has also increased in recent years; the simultaneous increase in the prevalence of cancer and metabolic syndrome prompted us to explore the common pathways between different cancers and metabolic syndrome to find common therapeutic targets.
- Methods: So, we have searched all 129 previously published studies to evaluate the shared pathways and mechanisms between all types of cancer and metabolic syndrome.
- Results: our results demonstrated the most critical common mechanisms between cancer and metabolic syndrome are chronic inflammation, insulin resistance, and different hormonal levels.Our results also demonstrated that colon, liver, and breast cancer are among the most essential cancers that have been proven to be associated with metabolic syndrome. endometrial, colorectal, gastric, bladder, and prostate cancer are also linked to obesity, which is one of the most significant markers of metabolic syndrome.
- Conclusion: Several mechanisms and pathways, including insulin resistance, chronic inflammation, and differences in different hormone levels, have linked metabolic syndrome to several cancers, including colon, liver, and breast cancer
- Keywords: metabolic syndrome, cancer, common pathways, mechanisms
