• info@icbcongress.com
• English
• Persian

• Login

Create Free Account

INTERNATIONAL CONGRESS OF

CancerGenetics

• Curcumin-based nanoformulations; a new approach for cancer therapy

• Fereshteh Alizadeh,¹ Sara Daneshjou,^2,*
  1. 1PhD Student of Nanobiotechnology, Department of Nanobiotechnology, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran
  2. 2Assistant Professor, Department of Nanobiotechnology, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran
  
  
  
• Introduction: Cancer is responsible for one-fifth of deaths worldwide every year. Cancer is the result of genetic and epigenetic changes that lead to apoptosis, uncontrolled cell proliferation, metastasis, and angiogenesis. In recent years, surgical methods, chemotherapy, and radiotherapy have been used to fight cancer. Still, these methods not only cause pain and discomfort to patients but also require drug resistance and have many side effects. Therefore, researchers have decided to use natural materials that are multifunctional in cancer. In this context, curcumin is a chemical substance extracted from the turmeric plant used to treat many types of cancer due to its anti-inflammatory, antioxidant, and anticarcinogenic properties. However, its efficacy is limited due to rapid metabolism, low bioavailability, and poor solubility in water, and systemic excretion is limited, so researchers have tried to solve these limitations by looking for drug delivery systems such as different nanostructures (polymeric nanoparticles, lipid nanoparticles, etc.).
• Methods: This review article is the result of several reviews by the authors, collected from reliable scholarly sources such as Scopus, Web of Science, PubMed.
• Results: Curcumin acts on several important targets, including protein kinase C (PKC), thioredoxin reductase, tubulin, 5-lipoxygenase, COX-2, cytokines, transcription factors, enzymes, growth factors and their receptors, and genes involved in cellular proliferation and apoptosis and through different molecular pathways, it can help treat cancer. many studies have shown that Curcumin nanoformulations have the potential to offer several benefits, including improved efficacy and tumor targeting, reduced systemic toxic effects, better compliance, and ease of administration.
• Conclusion: Studies have shown that curcumin-based nanoformulations have promising anti-cancer activity in various types of cancer, including breast, lung, prostate, colorectal cancer and etc. These nanoformulations have been found to inhibit cancer cell proliferation, induce cell death and prevent cancer metastasis. Despite the development of different nanocarriers for curcumin for cancer treatment, side effects such as interactions with other drugs and the toxicity of nanoparticles should be considered. For this reason, further studies should be conducted to prove the clinical efficacy of curcumin nanocarriers and Further research is needed to optimize the design and delivery of these nanoformulations and to evaluate their safety and efficacy in clinical trials.
• Keywords: Cancer treatment, Curcumin, Nanotechnology.