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INTERNATIONAL CONGRESS OF

CancerGenetics

• A review of the epidemiology and risk factors of skin cancer in solid organ transplant recipients

• Marziyeh Mirzalou,^1,* Mahdiyeh Mirzalou,²
  1. Bachelor student of microbiology, Islamic Azad Faculty of Biosciences and Technologies, Marand, Marand, Iran
  2. Bachelor student of microbiology, Islamic Azad Faculty of Biosciences and Technologies, Marand, Marand, Iran
  
  
  
• Introduction: The skin is the most common site for malignancy, with organ transplant recipients requiring chronic immunosuppression and contributing to an increased risk of skin cancer. In particular, squamous cell carcinoma of the skin and basal cell carcinoma are often identified.
• Methods: In order to identify studies aimed at epidemiology and risk factors of skin cancer in solid organ transplant recipients, this systematic review was conducted in Google Scholar, Science Direct, PubMed databases based on the keywords Skin cancer, Organ transplant, Safety system. After reviewing the summary of the articles and checking the title, irrelevant articles were removed and the full text of the articles was searched and the articles related to the topic were included in the study.
• Results: According to the studies, several factors such as patient characteristics, transplant type, severity, type and duration of immunosuppression, geographical location and exposure to sunlight can affect the probability of skin cancer in these patients. The incidence of skin cancer in organ transplant recipients varies by geographic location, with squamous cell carcinoma of the skin and basal cell carcinoma accounting for more than 90% of skin malignancies in organ transplant recipients.
• Conclusion: The role of immunosuppression as a precipitating factor for the development of skin cancer in organ transplant recipients is generally accepted, and the effect of these specific factors is also unclear; Although the overall level of immunosuppression appears to be an important factor in the development of skin cancers.
• Keywords: Skin cancer, Organ transplant, Immune system