INTERNATIONAL CONGRESS OF
CancerGenetics
Oncolytic Viruses in Gastric Cancer treatment
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Mohammad Amir Parvin,1,*
1. Department of Cell and Molecular Biology, school of Biology, University of Tehran, Tehran, Iran
- Introduction: Oncolytic viruses are among the viruses used in cancer treatment. They are defined as genetically engineered or naturally occurring viruses that selectively replicate and kill cancer cells without harming the normal tissues.Oncolytic viruses have unique mechanisms of action compared to currently available treatments. These viruses can modify the tumor microenvironment from a cold to a hot state by increasing immune cell infiltration in the tumor microenvironment. The use of oncolytic viruses to treat colorectal, pancreatic, and liver cancers in phases I and II clinical trials. associated with malignant melanoma cancer has been approved by the US Food and Drug Administration (FDA) in 2015.
- Methods: This article is a review article that contains resources from PubMed, Science Direct, Elsevier, and Google Scholar. A total of 108 articles (2004-2024) were collected and, finally, 45 articles were reviewed.
- Results: Despite the challenges and complexities of the treatment of oncolytic viruses, it is still a high potential therapeutic approach being used more often with the advancement of science and technology.
- Conclusion: The use of oncolytic viruses has created a new horizon in the treatment of cancers, such as gastrointestinal cancers that can enhance treatment accuracy by combining other methods.
- Keywords: Oncolytic viruses, gastric cancer, immunotherapy
