INTERNATIONAL CONGRESS OF
CancerGenetics
What about the world of colorectal cancer?
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Ali Rezaeian,1 Atefeh Kamran,2 Zahra Amirkhani,3,*
1. Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran.
2. Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran.
3. Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran.
- Introduction: Colon cancer (CRC) was the third most common cancer and the second leading cause of cancer-related mortality, and is associated with high disease worldwide, according to estimates from the International Agency for Cancer Research (IARC) over recent years . Colon cancer (CRC) is a heterogeneous disease, and most CRCs develop slowly from adenomatous or adenomas2 polyps . In addition to the adenoma sequence to cancer, about 25 % of scattered CRCs are caused by toothed precursor lesions 3. The risk of developing CRC can also be associated with age, male gender, genetics, environment, socioeconomic status, nutritional status, physical activity, smoking, and lifestyle factors. Currently, the proportion of older people with CRC has increased ; in 2050, about 6.9 million new CSCs will be diagnosed in adults aged 80 or over worldwide (20.5% of all cancer cases) . By contrast, epidemiological studies have shown that the prevalence of CRC in young people is also gradually increasing. Our goal in this study is to examine the various therapeutic and diagnostic aspects of this cancer.
- Methods: In this study,15 articles published from 2016 to 2024, which were in the form of original research and systematic review were examined. The study used the keywords colorectal cancer, treatment of cancer, cancer management.
- Results: Various treatments can be used including Endoscopic Treatment Surgical Treatment Laparoscopic Surgery for Advanced Colon Cancer Total Mesorectal Excision and Lateral Lymph Node discovery for Lower Rectal Cancer and... Namberde. As for the endoscopic method, it can be noted that progress in the development of flexible endoscopes and endoscopic devices has increased the demand for minimally invasive treatments. After diagnosis, T1 CRC may be interrupted endoscopically in en bloc endoscopy mucosal incision and endoscopic sub-mucosal incision for large and complex lesions . More recently, anal endoscopic myctomy has been performed for anal lesions with severe fibrosis, in which decomposition is carried out between the inner circular and outer longitudinal muscle layers 10. Full-thick endoscopic cutting has also been made possible. But despite the rapid advancement of chemotherapy radiotherapy and immunotherapy surgery remains the only possible treatment for advanced CRC 15 therefore, improving surgical treatment options for advanced CRC is crucial.
- Conclusion: Currently, patients with advanced CRC are still primarily treated with surgery coupled with neodevent chemotherapy , auxiliary chemotherapy, and radiotherapy to improve surgical treatment. Due to features such as sharp breakdown along embryonic surfaces in the interfacial interface with a complete breakdown of regional lymph nodes, CME is recommended for colon cancer and tme for anal cancer. With the advent of individualized and personalized medicine, continuous improvement in advanced CRC treatment requires data support for randomized clinical trials, which are also needed to provide evidence to support appropriate bowel incision and central lymphadenectomy rates in colorectal cancer surgery. Further studies are needed to determine optimal approaches for surgical treatment of patients with advanced CRC.
- Keywords: colorectal cancer, treatment of cancer, cancer management.
